作者
Michela Borghesan, Gianluigi Mazzoccoli, Fareeba Sheedfar, Jude Oben, Valerio Pazienza, Manlio Vinciguerra
发表日期
2014/10/1
来源
Biochemical Society Transactions
卷号
42
期号
5
页码范围
1409-1413
出版商
Portland Press Ltd.
简介
Within nucleosomes, canonical histones package the genome, but they can be opportunely replaced with histone variants. The incorporation of histone variants into the nucleosome is a chief cellular strategy to regulate transcription and cellular metabolism. In pathological terms, cellular steatosis is an abnormal accumulation of lipids, which reflects impairment in the turnover of triacylglycerols, affecting any organ but mainly the liver. The present review aims to summarize the experimental evidence for histone variant functions in lipid metabolism.
学术搜索中的文章
M Borghesan, G Mazzoccoli, F Sheedfar, J Oben… - Biochemical Society Transactions, 2014