查看文章

Non-alcoholic-fatty-liver-disease (NAFLD) encompasses conditions associated to fat deposition in the liver, which are generally deteriorated during the aging process. MacroH2A1, a variant of histone H2A, is a key transcriptional regulator involved in tumorigenic processes and cell senescence, and featuring two alternatively splicing isoforms, macroH2A1. 1 and macroH2A1. 2. MacroH2A1. 1 binds with high affinity O-acetyl ADP ribose, a small metabolite produced by the reaction catalysed by NAD+-dependent deacetylase SIRT1, whereas macroH2A1. 2 is unable to do so. The functional significance of this binding is unknown. We previously reported that the hepatic levels of macroH2A1. 1 and macroH2A1. 2 are differentially expressed in mice models of NAFLD. Here we show that over-expression of macroH2A1. 1, but not of macroH2A1. 2, is able to protect hepatocytes against lipid accumulation. MacroH2A1. 1 …