作者
Rainbo Hultman, Okechi Boms, Stephen D Mague, Dalton Hughes, Victor Nadler, Kafui Dzirasa, Patrick J Casey
发表日期
2019/1/1
期刊
bioRxiv
页码范围
567628
出版商
Cold Spring Harbor Laboratory
简介
Much about the molecular mechanisms underlying seizure susceptibility remains unknown. A number of studies have indicated that the neurotrophic factor BDNF plays an important role in mediating seizure susceptibility. Recently, we found that the heterotrimeric G – protein, Gz, which is known to endogenously couple to monoaminergic receptors, such as serotonin, norepinephrine and dopamine receptors, regulates BDNF-induced signaling and development in cortical neurons. Interestingly, several of the receptors that Gz endogenously couples to have also been shown to be associated with seizure phenotypes (5HT1A-serotonin and D2 dopamine). Here we characterized seizure susceptibility in Gz-null mice, behaviorally and electrographically, finding that Gz-null mice have increased seizure susceptibility using a modified version of the pilocarpine model of status epilepticus. Local field potential (LFP) data recorded from six brain regions-amygdala, dorsal hippocampus, ventral hippocampus, motor cortex, somatosensory cortex, and thalamus-showed robust electrographic seizure activity for Gz-null mice compared with low or no seizure activity in wild-type controls.
学术搜索中的文章
R Hultman, O Boms, S Mague, D Hughes, V Nadler… - biorxiv, 2019