作者
Sunil Kumar, Sherilynn J Black, Rainbo Hultman, Steven T Szabo, Kristine D DeMaio, Jeanette Du, Brittany M Katz, Guoping Feng, Herbert E Covington, Kafui Dzirasa
发表日期
2013/1/16
期刊
Journal of Neuroscience
卷号
33
期号
3
页码范围
1116-1129
出版商
Society for Neuroscience
简介
Transcranial magnetic stimulation and deep brain stimulation have emerged as therapeutic modalities for treatment refractory depression; however, little remains known regarding the circuitry that mediates the therapeutic effect of these approaches. Here we show that direct optogenetic stimulation of prefrontal cortex (PFC) descending projection neurons in mice engineered to express Chr2 in layer V pyramidal neurons (Thy1–Chr2 mice) models an antidepressant-like effect in mice subjected to a forced-swim test. Furthermore, we show that this PFC stimulation induces a long-lasting suppression of anxiety-like behavior (but not conditioned social avoidance) in socially stressed Thy1–Chr2 mice: an effect that is observed >10 d after the last stimulation. Finally, we use optogenetic stimulation and multicircuit recording techniques concurrently in Thy1–Chr2 mice to demonstrate that activation of cortical projection …
学术搜索中的文章
S Kumar, SJ Black, R Hultman, ST Szabo, KD DeMaio… - Journal of Neuroscience, 2013