作者
Saborni Chakraborty, Joseph Gonzalez, Karlie Edwards, Vamsee Mallajosyula, Anthony S Buzzanco, Robert Sherwood, Cindy Buffone, Nimish Kathale, Susan Providenza, Markus M Xie, Jason R Andrews, Catherine A Blish, Upinder Singh, Haley Dugan, Patrick C Wilson, Tho D Pham, Scott D Boyd, Kari C Nadeau, Benjamin A Pinsky, Sheng Zhang, Matthew J Memoli, Jeffery K Taubenberger, Tasha Morales, Jeffrey M Schapiro, Gene S Tan, Prasanna Jagannathan, Taia T Wang
发表日期
2021/1
期刊
Nature immunology
卷号
22
期号
1
页码范围
67-73
出版商
Nature Publishing Group US
简介
Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure. Severe COVID-19 is characterized by an inflammatory signature, including high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi. Here we show that patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans. This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor. These results show that disease severity in …
学术搜索中的文章
S Chakraborty, J Gonzalez, K Edwards, V Mallajosyula… - Nature immunology, 2021