作者
Jaana A Hartiala, Yi Han, Qiong Jia, James R Hilser, Pin Huang, Janet Gukasyan, William S Schwartzman, Zhiheng Cai, Subarna Biswas, David-Alexandre Tregouet, Nicholas L Smith, Invent Consortium, CHARGE Consortium Hemostasis Working Group, Genius-CHD Consortium, Marcus Seldin, Calvin Pan, Margarete Mehrabian, Aldons J Lusis, Peter Bazeley, Yan V Sun, Chang Liu, Arshed A Quyyumi, Markus Scholz, Joachim Thiery, Graciela E Delgado, Marcus E Kleber, Winfried März, Laurence J Howe, Folkert W Asselbergs, Marion van Vugt, Georgios J Vlachojannis, Riyaz S Patel, Leo-Pekka Lyytikäinen, Mika Kähönen, Terho Lehtimäki, Tuomo VM Nieminen, Pekka Kuukasjärvi, Jari O Laurikka, Xuling Chang, Chew-Kiat Heng, Rong Jiang, William E Kraus, Elizabeth R Hauser, Jane F Ferguson, Muredach P Reilly, Kaoru Ito, Satoshi Koyama, Yoichiro Kamatani, Issei Komuro, Biobank Japan, Lindsey K Stolze, Casey E Romanoski, Mohammad Daud Khan, Adam W Turner, Clint L Miller, Redouane Aherrahrou, Mete Civelek, Lijiang Ma, Johan LM Björkegren, S Ram Kumar, WH Wilson Tang, Stanley L Hazen, Hooman Allayee
发表日期
2021/3/1
期刊
European heart journal
卷号
42
期号
9
页码范围
919-933
出版商
Oxford University Press
简介
Aims
While most patients with myocardial infarction (MI) have underlying coronary atherosclerosis, not all patients with coronary artery disease (CAD) develop MI. We sought to address the hypothesis that some of the genetic factors which establish atherosclerosis may be distinct from those that predispose to vulnerable plaques and thrombus formation.
Methods and results
We carried out a genome-wide association study for MI in the UK Biobank (n∼472 000), followed by a meta-analysis with summary statistics from the CARDIoGRAMplusC4D Consortium (n∼167 000). Multiple independent replication analyses and functional approaches were used to prioritize loci and evaluate positional candidate genes. Eight novel regions were identified for MI at the genome wide significance level, of which effect sizes at six loci were more robust for MI than for CAD without the presence …
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JA Hartiala, Y Han, Q Jia, JR Hilser, P Huang… - European heart journal, 2021