作者
Pawina Jiramongkolchai, Andrew Peterson, Dorina Kallogjeri, Jake J Lee, Sara Kukuljan, Adam Liebendorfer, John S Schneider, Cristine N Klatt‐Cromwell, Andrew J Drescher, Jay F Piccirillo
发表日期
2020/8
期刊
International forum of allergy & rhinology
卷号
10
期号
8
页码范围
936-943
简介
Background
There is no consensus regarding the best route of intranasal delivery of corticosteroids in the treatment of chronic rhinosinusitis (CRS). The study objective of this work was to compare the impact of mometasone furoate nasal spray (MFNS) vs mometasone nasal irrigation in the management of CRS patients who have not undergone sinus surgery.
Methods
A double‐blind, placebo‐controlled, randomized clinical trial was conducted in adults with CRS. Individuals with nasal polyps and/or history of sinus surgery were excluded. Patients were randomized to receive 8 weeks of either MFNS or mometasone nasal irrigation. The primary outcome measure was change in the 22‐item Sino‐Nasal Outcome Test (SNOT‐22) score between the 2 groups. Secondary outcome measures included patient global response to treatment and Lund‐Kennedy endoscopy scores.
Results
A total of 43 participants …
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P Jiramongkolchai, A Peterson, D Kallogjeri, JJ Lee… - International forum of allergy & rhinology, 2020