作者
Sarah B Goldberg, Kurt A Schalper, Scott N Gettinger, Amit Mahajan, Roy S Herbst, Anne C Chiang, Rogerio Lilenbaum, Frederick H Wilson, Sacit Bulent Omay, B Yu James, Lucia Jilaveanu, Thuy Tran, Kira Pavlik, Elin Rowen, Heather Gerrish, Annette Komlo, Richa Gupta, Hailey Wyatt, Matthew Ribeiro, Yuval Kluger, Geyu Zhou, Wei Wei, Veronica L Chiang, Harriet M Kluger
发表日期
2020/5/1
期刊
The Lancet Oncology
卷号
21
期号
5
页码范围
655-663
出版商
Elsevier
简介
Background
We did a phase 2 trial of pembrolizumab in patients with non-small-cell lung cancer (NSCLC) or melanoma with untreated brain metastases to determine the activity of PD-1 blockade in the CNS. Interim results were previously published, and we now report an updated analysis of the full NSCLC cohort.
Methods
This was an open-label, phase 2 study of patients from the Yale Cancer Center (CT, USA). Eligible patients were at least 18 years of age with stage IV NSCLC with at least one brain metastasis 5–20 mm in size, not previously treated or progressing after previous radiotherapy, no neurological symptoms or corticosteroid requirement, and Eastern Cooperative Oncology Group performance status less than two. Modified Response Evaluation Criteria in Solid Tumors (mRECIST) criteria was used to evaluate CNS disease; systemic disease was not required for participation. Patients were treated with …
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SB Goldberg, KA Schalper, SN Gettinger, A Mahajan… - The Lancet Oncology, 2020