作者
Francesca Romana Ponziani, Fabio Del Zompo, Antonio Nesci, Francesco Santopaolo, Gianluca Ianiro, Maurizio Pompili, Antonio Gasbarrini, “Gemelli against COVID‐19” group
发表日期
2020/9
期刊
Alimentary pharmacology & therapeutics
卷号
52
期号
6
页码范围
1060-1068
简介
Background
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection is frequently associated with liver test abnormalities.
Aims
To describe the evolution of liver involvement during SARS‐CoV‐2 infection and its effect on clinical course and mortality.
Methods
Data of 515 SARS‐CoV‐2‐positive patients were collected at baseline and during follow‐up, last evaluation or death. Stratification based on need for hospitalisation, severe disease and admission to intensive care unit (ICU) was performed. The association between liver test abnormalities (baseline and peak values) and ICU admission or death was also explored.
Results
Liver test abnormalities were found in 161 (31.3%) patients. Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) were increased in 20.4%, 19% and 13.6% of patients, respectively. Baseline liver test abnormalities …
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FR Ponziani, F Del Zompo, A Nesci, F Santopaolo… - Alimentary pharmacology & therapeutics, 2020