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Inflammatory cytokines are a heterogeneous group which comprises the interleukin (IL)-1 family. The IL-1 family is made up of 11 different cytokines: IL-1α, IL-1β, IL-1Rantagonist (IL-1Ra), IL-18, IL-36Ra, IL-36α, IL-37, IL-36β, IL-36γ, IL-38 and IL-33 (1). Cytokines belonging to the IL-1 family present the same structure at the C-terminus, a β-trefoil fold made up of 12-β-strands connected by 11 loops. The pathways through which they are produced and activated are quite different from one another, ranging from nuclear expression and activation, to caspase-depending activation (2). Their functions also differ considerably, as some of these cytokines are involved in inflammatory pathways (IL-1α, IL-1β, IL-18, IL-36α, IL-36β, IL-36γ and IL-33), others have anti-inflammatory properties (IL-37) and others work as antagonists of other IL belonging to the IL-1 family (IL-1Ra and IL-36Ra). Yet, the differences in their function appear to be primarily associated to the different IL-receptors (IL-R)(3). The IL-R family is made up of 10 different receptors of which IL-1R8, IL-1R9 and IL-1R10 are anti-inflammatory pathway