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BACKGROUND:

Sleep disturbances are highly prevalent in people with multiple sclerosis (MS), and are associated with pain, fatigue, depression, and reduced quality of life (QoL). Importantly, sleep has been considered a critical brain state for motor learning and memory consolidation. Therefore, interventions that target sleep managementin people with MS are needed.

OBJECTIVES:

To explore the effects of a six weeks moderate-intensity aerobic exercise intervention on sleep characteristics and sleep-related biomarkers specifically serotonin, melatoninand cortisol in people with MS using a pilot randomized controlled trial.

METHODS:

Participants were randomly allocated to either a moderate-intensity aerobic exercise program (MAE, n= 20) or a home exercise program (HEP, n= 20). Participants were assessed at baseline and follow-up. Subjective and objective measures were used to assess sleep quality. The …