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In this article, a comprehensive approach is proposed for 5G communication networks. In SDATP, a slice-level customized protocol is developed for supporting time-critical services that require high reliability and low-latency, such as MTC services for industrial automation. To satisfy service quality requirements for an MTC service, we introduce in-network intelligence in the proposed protocol, by enabling the functionalities of in-path caching, in-path retransmission, in-network congestion detection and congestion control. To minimize the E2E delay, we optimize the configuration of caching functionalities, including the number of enabled caching nodes, caching node placement, and probabilistic packet caching policy. Since the optimization problem is NP-hard, we simplify the problem by reducing the number of decision variables and propose a low-complexity algorithm to solve the simplified problem. Extensive …