作者
Maaike Rijkers, Anno Saris, Sebastiaan Heidt, Arend Mulder, Leendert Porcelijn, Frans HJ Claas, Ruben Bierings, Frank WG Leebeek, AJ Gerard Jansen, Gestur Vidarsson, Jan Voorberg, Masja de Haas
发表日期
2018/10
期刊
Haematologica
卷号
103
期号
10
页码范围
1741-1752
出版商
Ferrata Storti Foundation
简介
HLA antibodies are associated with refractoriness to platelet transfusion, leading to rapid platelet clearance, sometimes coinciding with clinical side effects such as fever and chills. The presence of HLA antibodies is not always manifested by clinical symptoms. It is currently unclear why refractoriness to platelet transfusion is only observed in a subset of patients. Here, we utilized the availability of a unique panel of human monoclonal antibodies to study whether these were capable of activating platelets. Three out of eight human HLA-specific monoclonal antibodies induced activation of HLA-matched platelets from healthy donors as evidenced by enhanced α-granule release, aggregation, and α IIb b 3 activation. The propensity of HLA monoclonal antibodies to activate platelets was independent of the HLA subtype to which they were directed, but was dependent on the recognized epitope. Activation was fully …
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M Rijkers, A Saris, S Heidt, A Mulder, L Porcelijn… - haematologica, 2018