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Context: The COVID-19 outbreak was first experienced in China and rapidly spread to 212 countries/regions of the world, including Pakistan. It has affected both males and females, but the incidence is higher in males than in females worldwide.

Evidence Acquisition: According to the Ministry of National Health Services, Regulation, and Coordination of Pakistan, the female infection rate is much lower than the male infection rate in Pakistan (3.6% vs. 6.7%, respectively). What are the main possible reasons that created gender disparity in COVID-19 incidence in Pakistan? We reviewed different factors that created gender disparity in COVID-19 Incidence in Pakistan.

Results: The biological differences, social, professional, religious, psychological factors, cultural, and lifestyle aspects have created a gender disparity in COVID-19 incidence in Pakistan.

Conclusion: This study mainly focused on the main possible reasons (mentioned above) that COVID-19 has affected men more than women worldwide, especially in Pakistan.