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Several R&D issues need to be resolved in tomorrow’s eHealth care platforms to support personal health management services as well as mobility of patients and health professionals, by seamlessly integrating these services with smart surroundings that use self-configuring devices, intelligent agent technology and tools for ambient awareness and decision support. Such services, when interoperating with a life-long electronic health record of a citizen, can become the cornerstone for supporting continuity of care and cost effective health care for all. This paper discusses the architectural considerations and the R&D issues addressed in the design, development and implementation of the Ambient Intelligent platform for Cardiology (AmICa), a modular and flexible ambient intelligent eHealth platform for remote multiparametric monitoring of patients, able to be adapted to different care provision modes and daily life situations.