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Natural small molecule surfactants (lecithin and quillaja saponin) were used to fabricate nanoemulsion-based delivery systems from vitamin E acetate using high pressure homogenization. The effect of oil composition (0–100% vitamin E acetate), surfactant type, and surfactant concentration (0.0005–5%) on the mean particle diameter (d₃₂) and vitamin loading capacity was examined. The mean particle diameter had a minimum value at an intermediate vitamin E-to-orange oil ratio in the oil phase: d₃₂ = 0.13 μm for lecithin and 0.12 μm for quillaja saponin at 50% vitamin E. The mean particle diameter decreased with increasing surfactant concentration for both surfactants, with lower levels of quillaja saponin being required to form small droplets. The effect of pH, ionic strength, and temperature on the physical stability of the nanoemulsions was also investigated. Both surfactants formed unstable nanoemulsions at …