作者
Caroline Ovadia, Paul T Seed, Alexandros Sklavounos, Victoria Geenes, Chiara Di Ilio, Jenny Chambers, Katherine Kohari, Yannick Bacq, Nuray Bozkurt, Romana Brun-Furrer, Laura Bull, Maria C Estiú, Monika Grymowicz, Berrin Gunaydin, William M Hague, Christian Haslinger, Yayi Hu, Tetsuya Kawakita, Ayse G Kebapcilar, Levent Kebapcilar, Jūratė Kondrackienė, Maria PH Koster, Aneta Kowalska-Kańka, Limas Kupčinskas, Richard H Lee, Anna Locatelli, Rocio IR Macias, Hanns-Ulrich Marschall, Martijn A Oudijk, Yael Raz, Eli Rimon, Dan Shan, Yong Shao, Rachel Tribe, Valeria Tripodi, Cigdem Yayla Abide, Ilter Yenidede, Jim G Thornton, Lucy C Chappell, Catherine Williamson
发表日期
2019/3/2
期刊
The Lancet
卷号
393
期号
10174
页码范围
899-909
出版商
Elsevier
简介
Background
Intrahepatic cholestasis of pregnancy is associated with adverse perinatal outcomes, but the association with the concentration of specific biochemical markers is unclear. We aimed to quantify the adverse perinatal effects of intrahepatic cholestasis of pregnancy in women with increased serum bile acid concentrations and determine whether elevated bile acid concentrations were associated with the risk of stillbirth and preterm birth.
Methods
We did a systematic review by searching PubMed, Web of Science, and Embase databases for studies published from database inception to June 1, 2018, reporting perinatal outcomes for women with intrahepatic cholestasis of pregnancy when serum bile acid concentrations were available. Inclusion criteria were studies defining intrahepatic cholestasis of pregnancy based upon pruritus and elevated serum bile acid concentrations, with or without raised liver …
学术搜索中的文章
C Ovadia, PT Seed, A Sklavounos, V Geenes, C Di Ilio… - The Lancet, 2019