作者
Anna P Kenyon, C Nelson Piercy, J Girling, C Williamson, RM Tribe, AH Shennan
发表日期
2002/3/1
期刊
BJOG: an international journal of obstetrics and gynaecology
卷号
109
期号
3
页码范围
282-288
出版商
No longer published by Elsevier
简介
OBJECTIVE
To determine the nature and outcome of obstetric cholestasis in a United Kingdom population.
DESIGN
Prospective analysis of clinical outcome in women diagnosed with obstetric cholestasis that is actively managed.
SETTING
Antenatal population of three London hospitals between August 1999 and April 2001.
POPULATION
Seventy women with obstetric cholestasis defined as abnormal liver function (one or more abnormality in gamma-glutamyl transpeptidase, alanine amino-transferase, aspartate amino-transferase and total bile acids) in a pregnant woman with pruritus, in the absence of other pathology.
METHODS
All women were interviewed weekly regarding their symptoms. All were actively managed according to a standardised protocol, which included early delivery before 38 weeks. Obstetric outcome was recorded.
RESULTS
Seventy women of mean age 30 (6) years delivered 73 infants …
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AP Kenyon, CN Piercy, J Girling, C Williamson… - BJOG: an international journal of obstetrics and …, 2002