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Objective  To explore the clinical features of obstetric cholestasis pregnancies in UK white Caucasians.

Design  A questionnaire survey.

Setting  Study coordinated at Queen Charlotte's Hospital.

Population  Clinical features of 352 affected pregnancies in 227 Caucasian women identified via a patient support group.

Methods  Evaluation of the gestation at which prematurity and intrauterine death occur, and recording of additional clinical features in pregnancies complicated by obstetric cholestasis.

Main outcome measures  The timing of pregnancies complicated by intrauterine death and prematurity.

Results  Among the affected pregnancies, 23 (7%) were complicated by intrauterine death (20 singletons and 3 twins) and 133 (38%) were delivered prematurely (56 spontaneous and 77 iatrogenic). Eighteen of the 20 singleton intrauterine deaths occurred after 37 weeks. All three intrauterine deaths in twin …