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In this research, we apply robust optimization (RO) to the problem of locating facilities in a network facing uncertain demand over multiple periods. We consider a multi‐period fixed‐charge network location problem for which we find (1) the number of facilities, their location and capacities, (2) the production in each period, and (3) allocation of demand to facilities. Using the RO approach we formulate the problem to include alternate levels of uncertainty over the periods. We consider two models of demand uncertainty: demand within a bounded and symmetric multi‐dimensional box, and demand within a multi‐dimensional ellipsoid. We evaluate the potential benefits of applying the RO approach in our setting using an extensive numerical study. We show that the alternate models of uncertainty lead to very different solution network topologies, with the model with box uncertainty set opening fewer, larger facilities …