作者
Arman T Askari, Samuel Unzek, Zoran B Popovic, Corey K Goldman, Farhad Forudi, Matthew Kiedrowski, Aleksandr Rovner, Stephen G Ellis, James D Thomas, Paul E DiCorleto, Eric J Topol, Marc S Penn
发表日期
2003/8/30
期刊
The Lancet
卷号
362
期号
9385
页码范围
697-703
出版商
Elsevier
简介
Background
Myocardial regeneration via stem-cell mobilisation at the time of myocardial infarction is known to occur, although the mechanism for stem-cell homing to infarcted tissue subsequently and whether this approach can be used for treatment of ischaemic cardiomyopathy are unknown. We investigated these issues in a Lewis rat model (ligation of the left anterior descending artery) of ischaemic cardiomyopathy.
Methods
We studied the effects of stem-cell mobilisation by use of granulocyte colony-stimulating factor (filgrastim) with or without transplantation of syngeneic cells. Shortening fraction and myocardial strain by tissue doppler imaging were quantified by echocardiography.
Findings
Stem-cell mobilisation with filgrastim alone did not lead to engraftment of bone-marrow-derived cells. Stromal-cell-derived factor 1 (SDF-1), required for stem-cell homing to bone marrow, was upregulated immediately after …
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AT Askari, S Unzek, ZB Popovic, CK Goldman, F Forudi… - The Lancet, 2003