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With the recent emergence of novel technologies, the field of biomarker discovery has been the subject of intense research and activity. Major advances in cancer control will be greatly aided by early detection for the diagnosis and treatment of cancer in its pre-invasive state. Cancer being a diverse disease involves alterations in three classes of genes viz. (proto) oncogenes, tumour suppressor genes and DNA repair genes offering a wide variety of opportunities for the development of biomarkers. The emergence of innovative technologies in genomics, proteomics, metabolomics and imaging allows researchers to facilitate inclusive analysis of cancer cells. These approaches have already demonstrated its power to discriminate cancer cells from normal cells and to identify specific genetic elements involved in cancer progression. Cancer evolves via manifold pathways and is a culmination of a variety of genetic …