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Optical models of the human cornea and tear film typically employ a single homogeneous cornea with an average refractive index. I propose to use a more realistic multilayer model based on morphological data from the literature. The mathematical methodology to derive the refractive power equation of this model is presented. Special attention is given to the axial gradient index of the refraction structure of the stroma layer because of its optical implications. The importance of considering this multilayer model is quantified in a specific example (orthokeratology) with the help of the derived power equation.