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Nowadays, data size is increasing day by day from gigabytes to terabytes or even petabytes, mainly because of the evolution of a large amount of real-time data. Most of the big data is transmitted through the internet and they are stored on the cloud computing environment. As cloud computing provides internet-based services, there are many attackers and malicious users. They always try to access user’s confidential big data without having the access right. Sometimes, they replace the original data by any fake data. Therefore, big data security has become a significant concern recently. Deoxyribonucleic Acid (DNA) computing is an advanced emerged field for improving data security, which is based on the biological concept of DNA. A novel DNA based data encryption scheme has been proposed in this paper for the cloud computing environment. Here, a 1024-bit secret key is generated based on DNA computing …