作者
Angelika Erhardt, Ludwig Czibere, Darina Roeske, Susanne Lucae, Paul G Unschuld, Stephan Ripke, Michael Specht, Martin A Kohli, Stefan Kloiber, Marcus Ising, Angela Heck, Hildegard Pfister, Petra Zimmermann, Roselind Lieb, Benno Pütz, Manfred Uhr, Peter Weber, JM Deussing, Marya Gonik, Mirjam Bunck, MS Keßler, Elizabeth Frank, Christa Hohoff, Katharina Domschke, Petra Krakowitzky, Wolfgang Maier, Borwin Bandelow, C Jacob, Juergen Deckert, Stefan Schreiber, Jana Strohmaier, Markus Noethen, Sven Cichon, Marcella Rietschel, Thomas Bettecken, Martin E Keck, Rainer Landgraf, Bertram Müller-Myhsok, Florian Holsboer, EB Binder
发表日期
2011/6
期刊
Molecular psychiatry
卷号
16
期号
6
页码范围
647-663
出版商
Nature Publishing Group
简介
The lifetime prevalence of panic disorder (PD) is up to 4% worldwide and there is substantial evidence that genetic factors contribute to the development of PD. Single-nucleotide polymorphisms (SNPs) in TMEM132D, identified in a whole-genome association study (GWAS), were found to be associated with PD in three independent samples, with a two-SNP haplotype associated in each of three samples in the same direction, and with a P-value of 1.2 e− 7 in the combined sample (909 cases and 915 controls). Independent SNPs in this gene were also associated with the severity of anxiety symptoms in patients affected by PD or panic attacks as well as in patients suffering from unipolar depression. Risk genotypes for PD were associated with higher TMEM132D mRNA expression levels in the frontal cortex. In parallel, using a mouse model of extremes in trait anxiety, we could further show that anxiety-related …
学术搜索中的文章
A Erhardt, L Czibere, D Roeske, S Lucae, PG Unschuld… - Molecular psychiatry, 2011