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Supply chain operations have entered the digital era with the emergence of blockchain technology. In this paper, we discuss how the mean–variance (MV) approach can be applied to explore global supply chain operations risk with air logistics in the blockchain technology era. To be specific, we examine the related literature from four areas, namely air-logistics operations, demand management, supply management, and supply-demand coordination. We propose how the blockchain technology can be applied to facilitate the implementation of mean-variance risk analysis for global supply chain operations. We then highlight several promising areas for further studies. A future research agenda is developed.