作者
Luzia Valentini, Alessandro Pinto, Isabelle Bourdel-Marchasson, Rita Ostan, Patrizia Brigidi, Silvia Turroni, Silvana Hrelia, Patrizia Hrelia, Stefan Bereswill, André Fischer, Emanuela Leoncini, Marco Malaguti, Christéle Blanc-Bisson, Jessica Durrieu, Liana Spazzafumo, Fabio Buccolini, Florence Pryen, Lorenzo Maria Donini, Claudio Franceschi, Herbert Lochs
发表日期
2015/8/1
期刊
Clinical nutrition
卷号
34
期号
4
页码范围
593-602
出版商
Churchill Livingstone
简介
Objectives
To assess the impact of a personalized diet, with or without addition of VSL#3 preparation, on biomarkers of inflammation, nutrition, oxidative stress and intestinal microbiota in 62 healthy persons aged 65–85 years.
Design
Open label, randomized, multicenter study. Primary endpoint: High-sensitivity C-reactive protein.
Setting
Community.
Interventions
Eight week web-based dietary advice (RISTOMED platform) alone or with supplementation of VSL#3 (2 capsules per day). The RISTOMED diet was optimized to reduce inflammation and oxidative stress.
Measurements
Blood and stool samples were collected on days 1 and 56.
Results
Diet alone reduced ESR (p = 0.02), plasma levels of cholesterol (p < 0.01) and glucose (p = 0.03). Addition of VSL#3 reduced ESR (p = 0.05) and improved folate (p = 0.007), vitamin B12 (p = 0.001) and homocysteine (p < 0.001) plasma levels. Neither intervention demonstrated …
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L Valentini, A Pinto, I Bourdel-Marchasson, R Ostan… - Clinical nutrition, 2015