作者
John D Hazle, R Jason Stafford, Roger E Price
发表日期
2002/2
期刊
Journal of Magnetic Resonance Imaging: An Official Journal of the International Society for Magnetic Resonance in Medicine
卷号
15
期号
2
页码范围
185-194
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Purpose
To further investigate the use of magnetic resonance‐guided focused ultrasound therapy (MRgFUS) as a noninvasive alternative to surgery in the local control of soft‐tissue tumors by ablating prescribed volumes of VX2 rabbit tumors and comparing with ablation of normal tissue volumes.
Materials and Methods
Small, ellipsoidal ablations at shallow depth were created using 5‐ to 15‐second sonication pulses at radio frequency (RF) powers of 50–125 W using a spherical, air‐backed transducer operating at 1.463 MHz under MR guidance in a 1.5‐T clinical scanner.
Results
Excellent correlation was observed between prescribed treatment volumes, MR thermal dosimetry, post‐treatment verification MRI, and histopathology. Multifocal ablations of VX2 tumors in rabbits at depths of up to 2.5 cm resulted in complete ablation of the prescribed treatment volume.
Conclusion
MRgFUS is an effective …
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JD Hazle, RJ Stafford, RE Price - Journal of Magnetic Resonance Imaging: An Official …, 2002