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To further investigate the use of magnetic resonance‐guided focused ultrasound therapy (MRgFUS) as a noninvasive alternative to surgery in the local control of soft‐tissue tumors by ablating prescribed volumes of VX2 rabbit tumors and comparing with ablation of normal tissue volumes.

Small, ellipsoidal ablations at shallow depth were created using 5‐ to 15‐second sonication pulses at radio frequency (RF) powers of 50–125 W using a spherical, air‐backed transducer operating at 1.463 MHz under MR guidance in a 1.5‐T clinical scanner.

Excellent correlation was observed between prescribed treatment volumes, MR thermal dosimetry, post‐treatment verification MRI, and histopathology. Multifocal ablations of VX2 tumors in rabbits at depths of up to 2.5 cm resulted in complete ablation of the prescribed treatment volume.

MRgFUS is an effective …