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Objective:

To estimate the global and regional distribution of HIV-1 subtypes and recombinants between 2000 and 2007.

Design:

Country-specific HIV-1 molecular epidemiology data were combined with estimates of the number of HIV-infected people in each country.

Methods:

Cross-sectional HIV-1 subtyping data were collected from 65 913 samples in 109 countries between 2000 and 2007. The distribution of HIV-1 subtypes in individual countries was weighted according to the number of HIV-infected people in each country to generate estimates of regional and global HIV-1 subtype distribution for the periods 2000–2003 and 2004–2007.

Results:

Analysis of the global distribution of HIV-1 subtypes and recombinants in the two periods indicated a broadly stable distribution of HIV-1 subtypes worldwide with a notable increase in the proportion of circulating recombinant forms (CRFs), a decrease in unique recombinant …