作者
Rachel A Murphy, Thomas C Register, Carol A Shively, J Jeffrey Carr, Yaorong Ge, Marta E Heilbrun, Steven R Cummings, Annemarie Koster, Michael C Nevitt, Suzanne Satterfield, Frances A Tylvasky, Elsa S Strotmeyer, Anne B Newman, Eleanor M Simonsick, Ann Scherzinger, Bret H Goodpaster, Lenore J Launer, Gudny Eiriksdottir, Sigurdur Sigurdsson, Gunnar Sigurdsson, Vilmundur Gudnason, Thomas F Lang, Stephen B Kritchevsky, Tamara B Harris
发表日期
2014/1/1
期刊
Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences
卷号
69
期号
1
页码范围
109-117
出版商
Oxford University Press
简介
Background
Knowledge of adipose composition in relation to mortality may help delineate inconsistent relationships between obesity and mortality in old age. We evaluated relationships between abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) density, mortality, biomarkers, and characteristics.
Methods
VAT and SAT density were determined from computed tomography scans in persons aged 65 and older, Health ABC (n = 2,735) and AGES-Reykjavik (n = 5,131), and 24 nonhuman primates (NHPs). Associations between adipose density and mortality (4–13 years follow-up) were assessed with Cox proportional hazards models. In NHPs, adipose density was related to serum markers and tissue characteristics.
Results
Higher density adipose tissue was associated with mortality in both studies with adjustment for risk factors …
学术搜索中的文章
RA Murphy, TC Register, CA Shively, JJ Carr, Y Ge… - Journals of Gerontology Series A: Biomedical Sciences …, 2014