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The present study has been designed to evaluate the anti-asthmatic activity of leaves of Cyamopsis tetragonoloba on in-vitro and in-vivo models. The anti-asthmatic activity was carried out on isolated guinea pig ileum preparation (in-vitro), histamine induced bronchospasm in guinea pigs and milk-induced leukocytosis and eosinophilia in mice. Results showed that, the aqueous extract of the leaves significantly inhibited (p< 0.05) the contractile effect of histamine. Both Aqueous and alcoholic extracts were found to inhibit (p< 0.001 and p< 0.05) bronchospasm induced by histamine in guinea pigs by varying degree. Treatment with aqueous as well as alcoholic extracts of the plant decrease blood eosinophilia and leukocyte count by 80% and 90% respectively. The leaves of the plant showed significant anti-histaminic effect in both in-vitro and in-vivo models and …