作者
Li Zhou, Jie-Liang Li, Yu Zhou, Jin-Biao Liu, Ke Zhuang, Jian-Feng Gao, Shi Liu, Ming Sang, Jian-Guo Wu, Wen-Zhe Ho
发表日期
2015/12/1
期刊
MHR: Basic science of reproductive medicine
卷号
21
期号
12
页码范围
917-929
出版商
Oxford University Press
简介
STUDY HYPOTHESIS
Is it possible to immunologically activate human cervical epithelial cells to produce antiviral factors that inhibit herpes simplex virus type 2 (HSV-2) replication?
STUDY FINDING
Our results indicate that human cervical epithelial cells possess a functional TLR3/RIG-I signaling system, the activation of which can mount an Interferon-λ (IFN-λ)-mediated anti-HSV-2 response.
WHAT IS KNOWN ALREADY
There is limited information about the role of cervical epithelial cells in genital innate immunity against HSV-2 infection.
STUDY DESIGN, SAMPLES/MATERIALS, METHODS
We examined the expression of toll-like receptors (TLRs) and retinoic acid-inducible I (RIG-I) in End1/E6E7 cells by real-time PCR. The IFN-λ induced by TLR3 and RIG-I activation of End1/E6E7 cells was also examined by real-time PCR and …
学术搜索中的文章
L Zhou, JL Li, Y Zhou, JB Liu, K Zhuang, JF Gao, S Liu… - MHR: Basic science of reproductive medicine, 2015