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Waste activated sludge pretreatment is effective in improving sludge hydrolysis rate and methane production. Our previous study revealed that sulfite could be a viable method for sludge pretreatment. To further improve methane production, this study employed an integrated strategy by combining sulfite and heat pretreatment. WAS from a local full-scale plant was pretreated with heat-enhanced sulfite pretreatment (HESP) at 25, 35, 55 °C. Compared with the control (no sulfite, 25 °C), soluble substances (e.g., chemical oxygen demand, protein, polysaccharides, nitrogen and phosphorus) could be significantly enhanced by the absence of sulfite and the increasing temperature. A variation of − 8.32–19.90% in cumulative methane production was observed. Moreover, methane production could be significantly enhanced by 14.15% at sulfite of 300 mg S/L and temperature of 35 °C, while kinetic analysis showed that the …