作者
Emily R Smith, Erin Oakley, Gargi Wable Grandner, Kacey Ferguson, Fouzia Farooq, Yalda Afshar, Mia Ahlberg, Homa Ahmadzia, Victor Akelo, Grace Aldrovandi, Beth A Tippett Barr, Elisa Bevilacqua, Justin S Brandt, Nathalie Broutet, Irene Fernández Buhigas, Jorge Carrillo, Rebecca Clifton, Jeanne Conry, Erich Cosmi, Fatima Crispi, Francesca Crovetto, Camille Delgado-López, Hema Divakar, Amanda J Driscoll, Guillaume Favre, Valerie J Flaherman, Chris Gale, Maria M Gil, Sami L Gottlieb, Eduard Gratacós, Olivia Hernandez, Stephanie Jones, Erkan Kalafat, Sammy Khagayi, Marian Knight, Karen Kotloff, Antonio Lanzone, Kirsty Le Doare, Christoph Lees, Ethan Litman, Erica M Lokken, Valentina Laurita Longo, Shabir A Madhi, Laura A Magee, Raigam Jafet Martinez-Portilla, Elizabeth M McClure, Tori D Metz, Emily S Miller, Deborah Money, Sakita Moungmaithong, Edward Mullins, Jean B Nachega, Marta C Nunes, Dickens Onyango, Alice Panchaud, Liona C Poon, Daniel Raiten, Lesley Regan, Gordon Rukundo, Daljit Sahota, Allie Sakowicz, Jose Sanin-Blair, Jonas Söderling, Olof Stephansson, Marleen Temmerman, Anna Thorson, Jorge E Tolosa, Julia Townson, Miguel Valencia-Prado, Silvia Visentin, Peter Von Dadelszen, Kristina Adams Waldorf, Clare Whitehead, Murat Yassa, Jim M Tielsch
发表日期
2023/1/1
期刊
BMJ Global Health
卷号
8
期号
1
页码范围
e009495
出版商
BMJ Specialist Journals
简介
Introduction
Despite a growing body of research on the risks of SARS-CoV-2 infection during pregnancy, there is continued controversy given heterogeneity in the quality and design of published studies.
Methods
We screened ongoing studies in our sequential, prospective meta-analysis. We pooled individual participant data to estimate the absolute and relative risk (RR) of adverse outcomes among pregnant women with SARS-CoV-2 infection, compared with confirmed negative pregnancies. We evaluated the risk of bias using a modified Newcastle-Ottawa Scale.
Results
We screened 137 studies and included 12 studies in 12 countries involving 13 136 pregnant women.
Pregnant women with SARS-CoV-2 infection—as compared with uninfected pregnant women—were at significantly increased risk of maternal mortality (10 studies; n=1490; RR 7.68, 95% CI 1.70 to 34.61); admission to intensive care unit (8 studies …
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