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Drawing on network theory, this study examines how the entrepreneurship orientation (EO)-performance nexus is intermediated by networks firms establish with government agencies, suppliers, and resource acquisition. Structural equation modelling is used to test the model on a sample of 556 women tourism entrepreneurs in Ghana and Nigeria. Findings indicate that EO positively influences firms’ social ties, resource acquisition, and performance. The results also indicate that establishing strong ties with government agencies leads to more resource acquisition among women owned tourism businesses than strong business ties with suppliers. Furthermore, business ties are more beneficial when they mediate the effect of EO on performance and become weak and negative when the effect is sequentially mediated by business ties and network resource acquisition. Political ties negatively influenced performance …