作者
Rhona A Beynon, Suzanne M Ingle, Ryan Langdon, Margaret May, Andy Ness, Richard M Martin, Matthew Suderman, Kate Ingarfield, Riccardo E Marioni, Daniel L McCartney, Tim Waterboer, Michael Pawlita, Caroline Relton, George Davey Smith, Rebecca C Richmond
发表日期
2022/12
期刊
Clinical Epigenetics
卷号
14
页码范围
1-13
出版商
BioMed Central
简介
Background
Epigenetic clocks are biomarkers of ageing derived from DNA methylation levels at a subset of CpG sites. The difference between age predicted by these clocks and chronological age, termed “epigenetic age acceleration”, has been shown to predict age-related disease and mortality. We aimed to assess the prognostic value of epigenetic age acceleration and a DNA methylation-based mortality risk score with all-cause mortality in a prospective clinical cohort of individuals with head and neck cancer: Head and Neck 5000. We investigated two markers of intrinsic epigenetic age acceleration (IEAAHorvath and IEAAHannum), one marker of extrinsic epigenetic age acceleration (EEAA), one optimised to predict physiological dysregulation (AgeAccelPheno), one optimised to predict lifespan (AgeAccelGrim) and a DNA methylation-based predictor of mortality (ZhangScore). Cox …
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RA Beynon, SM Ingle, R Langdon, M May, A Ness… - Clinical Epigenetics, 2022