作者
William C Nierman, Arnab Pain, Michael J Anderson, Jennifer R Wortman, H Stanley Kim, Javier Arroyo, Matthew Berriman, Keietsu Abe, David B Archer, Clara Bermejo, Joan Bennett, Paul Bowyer, Dan Chen, Matthew Collins, Richard Coulsen, Robert Davies, Paul S Dyer, Mark Farman, Nadia Fedorova, Natalie Fedorova, Tamara V Feldblyum, Reinhard Fischer, Nigel Fosker, Audrey Fraser, Jose L García, Maria J García, Arlette Goble, Gustavo H Goldman, Katsuya Gomi, Sam Griffith-Jones, Ryan Gwilliam, Brian Haas, Hubertus Haas, David Harris, Hiroyuki Horiuchi, Jiaqi Huang, Sean Humphray, Javier Jiménez, Nancy Keller, Hoda Khouri, Katsuhiko Kitamoto, Tetsuo Kobayashi, Sven Konzack, Resham Kulkarni, Toshitaka Kumagai, Anne Lafton, Jean-Paul Latgé, Weixi Li, Angela Lord, Charles Lu, William H Majoros, Gregory S May, Bruce L Miller, Yasmin Mohamoud, Maria Molina, Michel Monod, Isabelle Mouyna, Stephanie Mulligan, Lee Murphy, Susan O'Neil, Ian Paulsen, Miguel A Peñalva, Mihaela Pertea, Claire Price, Bethan L Pritchard, Michael A Quail, Ester Rabbinowitsch, Neil Rawlins, Marie-Adele Rajandream, Utz Reichard, Hubert Renauld, Geoffrey D Robson, Santiago Rodriguez De Cordoba, Jose M Rodríguez-Peña, Catherine M Ronning, Simon Rutter, Steven L Salzberg, Miguel Sanchez, Juan C Sánchez-Ferrero, David Saunders, Kathy Seeger, Rob Squares, Steven Squares, Michio Takeuchi, Fredj Tekaia, Geoffrey Turner, Carlos R Vazquez De Aldana, Janice Weidman, Owen White, John Woodward, Jae-Hyuk Yu, Claire Fraser, James E Galagan, Kiyoshi Asai, Masayuki Machida, Neil Hall, Bart Barrell, David W Denning
发表日期
2005/12/22
期刊
Nature
卷号
438
期号
7071
页码范围
1151-1156
出版商
Nature Publishing Group UK
简介
Aspergillus fumigatus is exceptional among microorganisms in being both a primary and opportunistic pathogen as well as a major allergen,,. Its conidia production is prolific, and so human respiratory tract exposure is almost constant. A. fumigatus is isolated from human habitats and vegetable compost heaps,. In immunocompromised individuals, the incidence of invasive infection can be as high as 50% and the mortality rate is often about 50% (ref. ). The interaction of A. fumigatus and other airborne fungi with the immune system is increasingly linked to severe asthma and sinusitis. Although the burden of invasive disease caused by A. fumigatus is substantial, the basic biology of the organism is mostly obscure. Here we show the complete 29.4-megabase genome sequence of the clinical isolate Af293, which consists of eight chromosomes containing 9,926 predicted genes. Microarray analysis revealed …
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