作者
Kamal Awad, Maria-Corina Serban, Peter Penson, Dimitri P Mikhailidis, Peter P Toth, Steven R Jones, Manfredi Rizzo, George Howard, Gregory YH Lip, Maciej Banach, Lipid and Blood Pressure Meta-analysis Collaboration
发表日期
2017/6/13
期刊
Journal of Clinical Lipidology
出版商
Elsevier
简介
Background
Evidence about the optimal time of day at which to administer statins is lacking.
Objective
The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile.
Methods
We searched PubMed, SCOPUS, Web of Science, and Embase databases (from inception up to July 24, 2016) to identify the relevant studies. Mean differences (MDs) between the change scores in lipid parameters were pooled using a fixed-effect model.
Results
Eleven articles with 1034 participants were eligible for the analysis. The pooled analysis comparing effects of morning vs evening administration of statins on plasma total cholesterol (TC; P = .10), high-density lipoprotein cholesterol (P = .90), and triglycerides (P = .45) was not statistically significant. Low-density lipoprotein cholesterol (LDL-C) lowering was statistically greater in the evening-dose group (MD: 3.24 mg/dL, 95% CI …
学术搜索中的文章
K Awad, MC Serban, P Penson, DP Mikhailidis… - Journal of clinical lipidology, 2017