作者
Kamal Awad, Mahmoud Mohamed Zaki, Maged Mohammed, Joanna Lewek, Carl J Lavie, Maciej Banach, Lipid and Blood Pressure Meta-analysis Collaboration Group
发表日期
2022/10/1
来源
Mayo Clinic Proceedings
卷号
97
期号
10
页码范围
1808-1823
出版商
Elsevier
简介
Objective
To synthesize more conclusive evidence on the anti-inflammatory effects of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs).
Methods
PubMed, Scopus, and Embase were searched from inception until March 1, 2021. We included randomized controlled trials (RCTs) that assessed the effect of ACEIs or ARBs, compared with placebo, on any of the following markers: C-reactive protein (CRP), interleukin 6 (IL-6), or tumor necrosis factor α (TNF-α). Mean changes in the levels of these markers were pooled as a weighted mean difference (WMD) with a 95% CI.
Results
Thirty-two RCTs (n=3489 patients) were included in the final analysis. Overall pooled analysis suggested that ACEIs significantly reduced plasma levels of CRP (WMD, −0.54 [95% CI, −0.88 to −0.21]; P=.002; I2=96%), IL-6 (WMD, −0.84 [95% CI, −1.03 to −0.64]; P<.001; I2=0%), and TNF-α (WMD, −12.75 …
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K Awad, MM Zaki, M Mohammed, J Lewek, CJ Lavie… - Mayo Clinic Proceedings, 2022