作者
JI Zwicker, R Karp Leaf, M Carrier
发表日期
2016/9/1
期刊
Journal of Thrombosis and Haemostasis
卷号
14
期号
9
页码范围
1736-1740
出版商
Elsevier
简介
Essentials
  • •
    Clinicians may be hesitant to administer anticoagulation in the setting of brain metastases or glioma.
  • •
    In this meta‐analysis, we identified nine retrospective cohort studies that met inclusion criteria.
  • •
    Anticoagulation did not increase the risk of intracranial hemorrhage in brain metastasis.
  • •
    In the setting of glioma, anticoagulation resulted in 3.8‐fold increase in intracranial hemorrhage.
Summary: Background
Venous thromboembolism commonly occurs in patients with brain tumors. Because of the high rate of spontaneous intracranial hemorrhage (ICH), the safety of therapeutic anticoagulation is commonly questioned.
Objective
We performed a meta‐analysis to evaluate whether therapeutic anticoagulation is associated with an increased risk of intracranial hemorrhage in patients with brain tumors.
Patients/Methods
A systematic literature search strategy was conducted. Summary statistics for ICH were obtained …
引用总数
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学术搜索中的文章
JI Zwicker, RK Leaf, M Carrier - Journal of Thrombosis and Haemostasis, 2016