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Kisspeptin (Kiss), neurokinin B (NKB) and dynorphin A (DynA), collectively known as the KNDy neurons in the hypothalamus, drive the activity of the reproductive axis through the regulation of gonadotropin releasing hormone (GnRH) release. These neurons project to the rostral hypothalamus and median eminence to relay peripheral signals such as estrogen levels and energy homeostasis to the GnRH neuron. As neuropeptides, the actions of Kiss and DynA are required to be modified enzymatically in the extracellular space to modulate downstream signaling, though the regulator of this process is unknown. Furthermore, Phoenixin, a recently identified neuropeptide produced in the hypothalamus, increases GnRH, GnRH receptor and Kisspeptin mRNAs, increases GnRH secretion and mediates ovarian cyclicity. EP24.15 (EC 3.4.24.15, thimet oligopeptidase) is a metallo‐endopeptidase, expressed throughout the …