作者
Y Han, D Guo, Y Chen, Z-R Tan, H-H Zhou
发表日期
2009/9/1
期刊
Xenobiotica
卷号
39
期号
9
页码范围
694-699
出版商
Taylor & Francis
简介
- The objective of this study was to investigate the effect of concomitantly administered silymarin on the pharmacokinetics of talinolol, a typical substrate for P-glycoprotein (P-gp), in healthy Chinese volunteers and its association with a multidrug resistance 1 (MDR1) C3435T genetic polymorphism.
- Eighteen healthy adult men (six MDR1 3435CC homozygotes, six MDR1 3435CT heterozygotes and six MDR1 3435TT homozygotes) were recruited in a two-phase, randomized, single-blind, crossover design. The pharmacokinetics of talinolol were measured after co-administration of placebo or 140 mg silymarin capsules three times daily for 14 days. Concentrations of talinolol in plasma were measured for up to 36 h after drug administration by liquid chromatography-mass spectrometry (HPLC-MS).
- The peak plasma concentration (Cmax) of talinolol was significantly higher after silymarin administration as compared …
学术搜索中的文章
Y Han, D Guo, Y Chen, ZR Tan, HH Zhou - Xenobiotica, 2009