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Several genome‐wide association studies have revealed a genetic background with respect to susceptibility to rheumatoid arthritis (RA). Although several individual case–control studies have evaluated the role of protein tyrosine phosphatase non‐receptor 22 (PTPN22) gene rs2476601 single nucleotide polymorphism (SNP) in conferring a risk for RA, the results have been conflicting. Hence, this meta‐analysis was aimed to provide a solution for this issue.

To search for studies assessing the association between the PTPN22 gene rs2476601 SNP and the risk of RA, a systematic search was conducted in the main databases, including PubMed, Scopus and Web of Science, prior to December 2019. The odds ratio (OR) and corresponding 95% confidence interval (CI) was calculated to assess the possibility of association risk.

The literature search identified 52 case–control studies …