作者
Danillo G Augusto, Lawton D Murdolo, Demetra SM Chatzileontiadou, Joseph J Sabatino Jr, Tasneem Yusufali, Noah D Peyser, Xochitl Butcher, Kerry Kizer, Karoline Guthrie, Victoria W Murray, Vivian Pae, Sannidhi Sarvadhavabhatla, Fiona Beltran, Gurjot S Gill, Kara L Lynch, Cassandra Yun, Colin T Maguire, Michael J Peluso, Rebecca Hoh, Timothy J Henrich, Steven G Deeks, Michelle Davidson, Scott Lu, Sarah A Goldberg, J Daniel Kelly, Jeffrey N Martin, Cynthia A Vierra-Green, Stephen R Spellman, David J Langton, Michael J Dewar-Oldis, Corey Smith, Peter J Barnard, Sulggi Lee, Gregory M Marcus, Jeffrey E Olgin, Mark J Pletcher, Martin Maiers, Stephanie Gras, Jill A Hollenbach
发表日期
2023/8/3
期刊
Nature
卷号
620
期号
7972
页码范围
128-136
出版商
Nature Publishing Group UK
简介
Studies have demonstrated that at least 20% of individuals infected with SARS-CoV-2 remain asymptomatic, , –. Although most global efforts have focused on severe illness in COVID-19, examining asymptomatic infection provides a unique opportunity to consider early immunological features that promote rapid viral clearance. Here, postulating that variation in the human leukocyte antigen (HLA) loci may underly processes mediating asymptomatic infection, we enrolled 29,947 individuals, for whom high-resolution HLA genotyping data were available, in a smartphone-based study designed to track COVID-19 symptoms and outcomes. Our discovery cohort (n = 1,428) comprised unvaccinated individuals who reported a positive test result for SARS-CoV-2. We tested for association of five HLA loci with disease course and identified a strong association between HLA-B*15:01 and asymptomatic infection, observed …
学术搜索中的文章
DG Augusto, LD Murdolo, DSM Chatzileontiadou… - Nature, 2023