作者
Mehdi C Shelhamer, Paul D Wesson, Ian L Solari, Deanna L Jensen, William Alex Steele, Vihren G Dimitrov, John Daniel Kelly, Shazia Aziz, Victor Perez Gutierrez, Eric Vittinghoff, Kevin K Chung, Vidya P Menon, Herman A Ambris, Sanjiv M Baxi
发表日期
2021/2
期刊
Journal of intensive care medicine
卷号
36
期号
2
页码范围
241-252
出版商
SAGE Publications
简介
Background
Coronavirus disease 2019 (COVID-19) can lead to acute respiratory distress syndrome (ARDS) but it is unknown whether prone positioning improves outcomes in mechanically ventilated patients with moderate to severe ARDS due to COVID-19.
Methods
A cohort study at a New York City hospital at the peak of the early pandemic in the United States, under crisis conditions. The aim was to determine the benefit of prone positioning in mechanically ventilated patients with ARDS due to COVID-19. The primary outcome was in-hospital death. Secondary outcomes included changes in physiologic parameters. Fine-Gray competing risks models with stabilized inverse probability treatment weighting (sIPTW) were used to determine the effect of prone positioning on outcomes. In addition, linear mixed effects models (LMM) were used to assess changes in physiology with prone positioning.
Results
Out of 335 …
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