作者
Michael J Peluso, Hannah M Sans, Carrie A Forman, Alyssa N Nylander, Hsi-en Ho, Scott Lu, Sarah A Goldberg, Rebecca Hoh, Viva Tai, Sadie E Munter, Ahmed Chenna, Brandon C Yee, John W Winslow, Christos J Petropoulos, Jeffrey N Martin, JD Kelly, Matthew S Durstenfeld, Priscilla Y Hsue, Peter W Hunt, Meredith Greene, Felicia C Chow, Joanna Hellmuth, Timothy J Henrich, David V Glidden, Steven G Deeks
发表日期
2022/6/14
期刊
Neurology: Neuroimmunology & Neuroinflammation
卷号
9
期号
5
页码范围
e200003
出版商
Lippincott Williams & Wilkins
简介
Background and Objectives
The biologic mechanisms underlying neurologic postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) are incompletely understood.
Methods
We measured markers of neurologic injury (glial fibrillary acidic protein [GFAP], neurofilament light chain [NfL]) and soluble markers of inflammation among a cohort of people with prior confirmed SARS-CoV-2 infection at early and late recovery after the initial illness (defined as less than and greater than 90 days, respectively). The primary clinical outcome was the presence of self-reported CNS PASC symptoms during the late recovery time point. We compared fold changes in marker values between those with and without CNS PASC symptoms using linear mixed-effects models and examined relationships between neurologic and immunologic markers using rank linear correlations.
Results
Of 121 …
学术搜索中的文章
MJ Peluso, HM Sans, CA Forman, AN Nylander, H Ho… - Neurology: Neuroimmunology & Neuroinflammation, 2022