作者
Beatriz Perez Villamil, Alejandro Romera Lopez, Susana Hernandez Prieto, Guillermo Lopez Campos, Antonio Calles, Jose Antonio Lopez Asenjo, Julian Sanz Ortega, Cristina Fernandez Perez, Javier Sastre, Rosario Alfonso, Trinidad Caldes, Fernando Martin Sanchez, Eduardo Diaz Rubio
发表日期
2012/12
期刊
BMC cancer
卷号
12
页码范围
1-13
出版商
BioMed Central
简介
Background
Colon cancer patients with the same stage show diverse clinical behavior dueto tumor heterogeneity. We aimed to discover distinct classes of tumorsbased on microarray expression patterns, to analyze whether the molecularclassification correlated with the histopathological stages or otherclinical parameters and to study differences in the survival.
Methods
Hierarchical clustering was performed for class discovery in 88 colon tumors(stages I to IV). Pathways analysis and correlations between clinicalparameters and our classification were analyzed. Tumor subtypes werevalidated using an external set of 78 patients. A 167 gene signatureassociated to the main subtype was generated using the 3-Nearest-Neighbormethod. Coincidences with other prognostic predictors were assesed.
Results
Hierarchical …
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B Perez Villamil, A Romera Lopez, S Hernandez Prieto… - BMC cancer, 2012