作者
Jesus F Bermejo-Martin, Ignacio Martin-Loeches, Jordi Rello, Andres Antón, Raquel Almansa, Luoling Xu, Guillermo Lopez-Campos, Tomás Pumarola, Longsi Ran, Paula Ramirez, David Banner, Derek Cheuk Ng, Lorenzo Socias, Ana Loza, David Andaluz, Enrique Maravi, Maria J Gómez-Sánchez, Mónica Gordón, Maria C Gallegos, Victoria Fernandez, Sara Aldunate, Cristobal León, Pedro Merino, Jesús Blanco, Fernando Martin-Sanchez, Lucia Rico, David Varillas, Veronica Iglesias, Maria Ángeles Marcos, Francisco Gandía, Felipe Bobillo, Begoña Nogueira, Silvia Rojo, Salvador Resino, Carmen Castro, Raul Ortiz de Lejarazu, David Kelvin
发表日期
2010/10
期刊
Critical Care
卷号
14
页码范围
1-12
出版商
BioMed Central
简介
Introduction
Pandemic A/H1N1/2009 influenza causes severe lower respiratory complications in rare cases. The association between host immune responses and clinical outcome in severe cases is unknown.
Methods
We utilized gene expression, cytokine profiles and generation of antibody responses following hospitalization in 19 critically ill patients with primary pandemic A/H1N1/2009 influenza pneumonia for identifying host immune responses associated with clinical outcome. Ingenuity pathway analysis 8.5 (IPA) (Ingenuity Systems, Redwood City, CA) was used to select, annotate and visualize genes by function and pathway (gene ontology). IPA analysis identified those canonical pathways differentially expressed (P < 0.05) between comparison groups. Hierarchical clustering of those genes differentially expressed between groups by IPA analysis …
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JF Bermejo-Martin, I Martin-Loeches, J Rello, A Antón… - Critical Care, 2010