作者
Maurizio Paciaroni, Giancarlo Agnelli, Valeria Caso, Giorgio Silvestrelli, David Julian Seiffge, Stefan Engelter, Gian Marco De Marchis, Alexandros Polymeris, Maria Luisa Zedde, Shadi Yaghi, Patrik Michel, Ashraf Eskandari, Kateryna Antonenko, Sung-Il Sohn, Manuel Cappellari, Tiziana Tassinari, Rossana Tassi, Luca Masotti, Aristeidis H Katsanos, Sotirios Giannopoulos, Monica Acciarresi, Andrea Alberti, Michele Venti, Maria Giulia Mosconi, Maria Cristina Vedovati, Patrizia Pierini, Michela Giustozzi, Enrico Maria Lotti, George Ntaios, Odysseas Kargiotis, Serena Monaco, Piergiorgio Lochner, Fabio Bandini, Chrysoula Liantinioti, Lina Palaiodimou, Azmil H Abdul-Rahim, Kennedy Lees, Michelangelo Mancuso, Leonardo Pantoni, Silvia Rosa, Pierluigi Bertora, Silvia Galliazzo, Walter Ageno, Elisabetta Toso, Filippo Angelini, Alberto Chiti, Giovanni Orlandi, Licia Denti, Yuriy Flomin, Simona Marcheselli, Nicola Mumoli, Alexandra Rimoldi, Elena Verrengia, Erika Schirinzi, Massimo Del Sette, Panagiotis Papamichalis, Apostolos Komnos, Nemanja Popovic, Marija Zarkov, Alessandro Rocco, Marina Diomedi, Elisa Giorli, Alfonso Ciccone, Brian C Mac Grory, Karen L Furie, Bruno Bonetti, Valentina Saia, Francesca Guideri, Maurizio Acampa, Giuseppe Martini, Elisa Grifoni, Marina Padroni, Efstathia Karagkiozi, Kalliopi Perlepe, Konstantinos Makaritsis, Marina Mannino, Miriam Maccarrone, Leonardo Ulivi, Nicola Giannini, Elena Ferrari, Alessandro Pezzini, Boris Doronin, Vera Volodina, Antonio Baldi, Cataldo D’Amore, Dirk Deleu, Francesco Corea, Jukka Putaala, Paola Santalucia, Katiuscia Nardi, Angela Risitano, Danilo Toni, Georgios Tsivgoulis
发表日期
2019/8
期刊
Stroke
卷号
50
期号
8
页码范围
2168-2174
出版商
Lippincott Williams & Wilkins
简介
Background and Purpose
Despite treatment with oral anticoagulants, patients with nonvalvular atrial fibrillation (AF) may experience ischemic cerebrovascular events. The aims of this case-control study in patients with AF were to identify the pathogenesis of and the risk factors for cerebrovascular ischemic events occurring during non–vitamin K antagonist oral anticoagulants (NOACs) therapy for stroke prevention.
Methods
Cases were consecutive patients with AF who had acute cerebrovascular ischemic events during NOAC treatment. Controls were consecutive patients with AF who did not have cerebrovascular events during NOACs treatment.
Results
Overall, 713 cases (641 ischemic strokes and 72 transient ischemic attacks; median age, 80.0 years; interquartile range, 12; median National Institutes of Health Stroke Scale on admission, 6.0; interquartile range, 10) and 700 controls (median age, 72.0 years …
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M Paciaroni, G Agnelli, V Caso, G Silvestrelli… - Stroke, 2019