作者
Xiao Liang, Runwei Guan, Jiamin Zhu, Yue Meng, Jing Zhu, Yuxiang Yang, Yanan Cui, Jiali Dai, Weidong Mao, Liting Lv, Dong Shen, Renhua Guo
发表日期
2023/10
期刊
Journal of Cancer Research and Clinical Oncology
卷号
149
期号
13
页码范围
12265-12274
出版商
Springer Berlin Heidelberg
简介
Background
The efficacy of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) was affected by numerous factors. In the study, we developed and validated an artificial neural network (ANN) system based on clinical characteristics and next-generation sequencing (NGS) to support clinical decisions.
Methods
A multicenter retrospective non-interventional study was conducted. 240 patients from three hospitals with advanced non-small cell lung cancer (NSCLC) and EGFR mutation were tested by NGS before the first treatment. All patients received formal EGFR-TKIs treatment. Five different models were individually trained to predict the efficacy of EGFR-TKIs based on one medical center with 188 patients. Two independent cohorts from other medical centers were collected for external validation.
Results
Compared with logistic regression, four machine learning methods showed better predicting …
学术搜索中的文章
X Liang, R Guan, J Zhu, Y Meng, J Zhu, Y Yang, Y Cui… - Journal of Cancer Research and Clinical Oncology, 2023